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ClinicalTrials.gov - A service of the U.S. National Institutes of Health

Selected Clinical Trials Using Mesenchymal Stem Cells (MSCs)

Listed below are some of the clinical trials underway using MSCs. For additional information about these and other clinical trials visit clinicaltrials.gov.

Autologous Mesenchymal Stromal Cell Therapy in Heart Failure

Sponsor: Rigshospitalet, Denmark

Intracoronary Infusion of Autologous Bone Marrow Cells for Treatment of Idiopathic Dilated Cardiomyopathy

Sponsor: Hospital Universitario Reina Sofia

Prospective Randomized Study of Mesenchymal Stem Cell Therapy in Patients Undergoing Cardiac Surgery (PROMETHEUS)

Sponsors: National Heart, Lung, and Blood Institute (NHLBI); Johns Hopkins University Specialized Center for Cell Based Therapy

Combined CABG and Stem-Cell Transplantation for Heart Failure

Sponsor: Helsinki University

The Transendocardial Autologous Cells (hMSC or hBMC) in Ischemic Heart Failure Trial (TAC-HFT)

Sponsor: University of Miami

Mesenchymal Stem Cells and Myocardial Ischemia

Sponsors: University Hospital, Toulouse; French Blood Establishment (Midi-Pyrénées); Nantes University Hospital; PHRC, Ministry of Health France

Induced Wound Healing by Application of Expanded Bone Marrow Stem Cells in Diabetic Patients With Critical Limb Ischemia

Sponsors: Ruhr University of Bochum

Intraarterial Infusion of Autologous Mesenchymal Stem Cells From Adipose Tissue in Diabetic Patients With Chronic Critical Limb Ischemia

Sponsor: Fundacion Progreso y Salud, Spain; Carlos III Health Institute Adipose Tissue in Diabetic Patients With Chronic Critical Limb Ischemia

Autologous Transplantation of Bone Marrow Mesenchymal Stem Cells on Diabetic Foot

Sponsor: Third Military Medical University

Intravenous Stem Cells After Ischemic Stroke

Sponsors: University Hospital, Grenoble; Commissariat à l'Energie Atomique; Institut National de la Santé Et de la Recherche Médicale, France

Autologous Mesenchymal Stem Cell Transplant for Parkinson's Disease

Sponsor: Jaslok Hospital and Research Centre

Autologous Mesenchymal Stem Cell (MSC) Transplantation in MS

Sponsors: The Cleveland Clinic; University Hospital Case Medical Center

Mesenchymal Stem Cells in Multiple Sclerosis (MSCIMS)

Sponsors: University of Cambridge; Cambridge University Hospitals NHS Foundation Trust; Medical Research Council

Mesenchymal Stem Cells for the Treatment of MS

Sponsor: Hadassah Medical Organization

Autologous Mesenchymal Stem Cells From Adipose Tissue in Patients With Secondary Progressive Multiple Sclerosis

Sponsors: Fundacion Progreso y Salud, Spain; Carlos III Health Institute

Treatment of Patients With Newly Onset of Type 1 Diabetes With Mesenchymal Stem Cells

Sponsor: Uppsala University Hospital

Cotransplantation of Islet and Mesenchymal Stem Cell in Type 1 Diabetic Patients

Sponsor: Fuzhou General Hospital

Mesenchymal Stem Cells Transplantation for Refractory Systemic Lupus Erythematosus (SLE)

Sponsors: Nanjing Medical University; National Natural Science Foundation of China

Effect of Mesenchymal Stem Cell Transplantation for Lupus Nephritis

Sponsor: Organ Transplant Institute, China

Mesenchymal Stem Cells and Subclinical Rejection

Sponsor: Leiden University Medical Center

Mesenchymal Stem Cell Transplantation in Recipients of Living Kidney Allografts

Sponsor: Fuzhou General Hospital

Long-Term Follow-up of Liver Failure Patients Who Received Autologous Mesenchymal Stem Cells ( MSCs) Transplantation

Sponsor: Sun Yat-sen University

Mesenchymal Stem Cell Transplantation in Decompensated Cirrhosis

Sponsor: University of Tehran

Improvement of Liver Function in Liver Cirrhosis Patients After Autologous Mesenchymal Stem Cell Injection: a Phase I-II Clinical Trial

Sponsors: Shaheed Beheshti Medical University; Tarbiat Modarres University: Department of Hematology

Trial of Autologous Mesenchymal Stem Cells in Patients With Multiple System Atrophy

Sponsor: Yonsei University

Autologous Transplantation of Mesenchymal Stem Cells (MSCs) and Scaffold in Full-Thickness Articular Cartilage

Sponsors: Royan Institute; Tehran University of Medical Sciences

The Use of Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Articular Cartilage Defects

Sponsor: Cairo University

Mesenchymal Stem Cells in a Clinical Trial to Heal Articular Cartilage Defects

Sponsor: Ullevaal University Hospital

Mesenchymal Stem Cell for Osteonecrosis of the Femoral Head

Sponsor: Fuzhou General Hospital

Using Mesenchymal Stem Cells to Fill Bone Void Defects in Patients With Benign Bone Lesions

Sponsor: Emory University

Autologous Implantation of Mesenchymal Stem Cells for the Treatment of Distal Tibial Fractures

Sponsors: Hadassah Medical Organization; Teva Pharmaceutical Industries

Percutaneous Autologous Bone-marrow Grafting for Open Tibial Shaft Fracture

Sponsors: University Hospital, Tours

Cord Blood Expansion on Mesenchymal Stem Cells

Sponsor: M.D. Anderson Cancer Center

Available at clinicaltrials.gov. Accessed March 24, 2010.

Medical treatments using cord tissue are still under development and have not yet been used in humans.

Banking cord blood does not guarantee that the cells will provide a cure or be applicable for every situation. For inherited genetic conditions, the child will not be able to use his or her own stem cells. A matched sibling's stem cells would be the first choice. Ultimate use will be determined by the treating physician. Treatment for brain injury and juvenile diabetes is experimental and currently requires the use of your own cord blood. Medical treatments using family banked cord tissue are in early research and are not available today; there is no guarantee that therapies will be developed in the future.
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